Chalcoplatin
WebJul 19, 2024 · 1. Introduction. The discovery of anticancer properties of platinum based complexes became a significant breakthrough in cancer treatment [].Currently cisplatin, carboplatin, and oxaliplatin remain major drugs for the first line treatment (alone and in combination) for a variety of malignancies including head and neck, testicular, breast, … WebMay 28, 2024 · Recently, Pt IV prodrugs have attracted much attention as the next generation of platinum-based antineoplastic drug candidates. Here we report the discovery and evaluation of monochalcoplatin, a …
Chalcoplatin
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WebAug 1, 2016 · Chalcoplatin, a dual-targeting and p53 activator-containing anticancer platinum(IV) prodrug with unique mode of action. Ma L, Ma R, Wang Y, Zhu X, Zhang J, Chan HC, Chen X, Zhang W, Chiu SK, Zhu G. Chem Commun (Camb), (29):6301-6304 2015 MED: 25644651 WebChalcoplatin significantly induced p53 activation as well as the subsequent apoptosis pathways. This unique mode of action renders chalcoplatin remarkably cytotoxic and makes this compound among the first examples of a Pt(IV) prodrug that directly interacts with the downstream pathway after the formation of Pt-DNA lesions.
Web1. Introduction. The discovery of anticancer properties of platinum based complexes became a significant breakthrough in cancer treatment [].Currently cisplatin, carboplatin, and oxaliplatin remain major drugs for the first line treatment (alone and in combination) for a variety of malignancies including head and neck, testicular, breast, and ovarian tumors … WebMay 28, 2024 · Recently, Pt IV prodrugs have attracted much attention as the next generation of platinum-based antineoplastic drug candidates. Here we report the …
WebMay 1, 2015 · Abstract. A nanoplatform targeting DNA and p53 simultaneously is assembled. Layered double hydroxide nanoparticles are co-loaded with a Pt (IV) prodrug and a p53 activator. Once inside cells, cisplatin is released to attack genomic DNA and kill cancer cells; simultaneously, the p53 activator results in active p53, a key protein … WebChalcoplatin significantly induced p53 activation as well as the subsequent apoptosis pathways. This unique mode of action renders chalcoplatin remarkably cytotoxic and …
WebHere we report the discovery and evaluation of monochalcoplatin, a monocarboxylated PtIV prodrug that is among the most cytotoxic PtIV prodrugs to date. Compared with its …
WebScheme 1.2 Synthesis of chalcoplatin 15 Scheme 1.3 Synthesis of curcumin derivative with different substituents at diaryl moieties. 17 Scheme 1.4 Synthesis of curcumin analogues with arylhydrazone at C-4 position. 18 Scheme 1.5 Synthesis of analogue 23 based on monocarbonyl by 3-carbon linker 19 Scheme 1.6 Synthesis of the bispropoxy analogue 20 how much snow has montana gottenWebUse SelfDecode to get personalized health recommendations based on your genes. Get started today with an existing DNA file or order a SelfDecode DNA kit! how do u no if u have breast cancerWebChalcoplatin, a dual-targeting and p53 activator-containing anticancer platinum( iv ) prodrug with unique mode of action. Chemical Communications 2015, 51 (29) , 6301-6304. DOI: 10.1039/C4CC10409A. Katarzyna A. Mocniak, Ilona Kubajewska, Dominic E. M. Spillane, Gareth R. Williams, Russell E. Morris. ... how do u nuke a discord serverWebDespite the enormous importance of cisplatin as a chemotherapeutic agent, its application is impacted by dose-limiting side effects and lack of selectivity for cancer cells. Researchers can overcome these issues by taking advantage of the pro-drug nature of the platinum(IV) oxidation state, and by modifying the coordination sphere of the metal centre with … how much snow has nyc gotten todayWebThe complex, called “chalcoplatin” by the authors, displayed significantly increased cytotoxicity in p53 wild-type but not in p53 null cells. Moreover, chalcoplatin effectively … how much snow has st paul gotWebJun 14, 2024 · Compared with its dicarboxylated counterpart chalcoplatin, monochalcoplatin accumulates astonishingly effectively and rapidly in cancer cells, which is not ascribed to its lipophilicity. The prodrug is quickly reduced, causes DNA damage, and induces apoptosis, resulting in superior cytotoxicity with IC50 values in the nanomolar … how do u pet boomer in far cry 5WebDownload scientific diagram RP-HPLC analysis of remainingPt IV complexes. 50 mm Pt IV complexesw ere incubated with and without 2mm sodium ascorbate in asolution of … how do u ping someone on discord